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Yes. These thesis topics are aligned with NMC, NBE and DNB Microbiology (TB & Molecular Diagnostics) curricula and suit MD, DNB Microbiology (TB & Molecular Diagnostics) and FCPS candidates alike.

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TB & Molecular Diagnostics Thesis Topics, MD Microbiology 2026

001

Prevalence of latent tuberculosis infection among healthcare workers detected by interferon-gamma release assay

Mycobacteriology Prospective analytical study Clinical Spectrum / Profile

Objective

MD Microbiology (TB & Molecular Diagnostics) — Thesis Title List

Prevalence of latent tuberculosis infection among healthcare workers detected by interferon-gamma release assay

Clinical and microbiological profile of tuberculosis in patients with HIV co-infection

Comparison of automated and conventional blood culture systems with respect to yield and time to positivity

Diagnostic yield of CBNAAT on gastric aspirate and induced sputum in paediatric pulmonary tuberculosis

Sputum smear and culture conversion at the end of intensive phase and its predictors in pulmonary tuberculosis

Detection of isoniazid and rifampicin resistance by line probe assay in pulmonary tuberculosis isolates

Diagnostic utility of fine needle aspiration cytology with CBNAAT in tuberculous lymphadenitis

Determinants of treatment adherence among patients with drug-sensitive pulmonary tuberculosis under NTEP

Screening for diabetes mellitus among patients with pulmonary tuberculosis and its association with sputum conversion

Patient and health system delay in diagnosis of pulmonary tuberculosis and its determinants

Treatment outcome and predictors of mortality in hospitalised patients with tuberculous meningitis

Diagnostic accuracy of urine dipstick and microscopy compared with urine culture in suspected urinary tract infection

Species identification of nontuberculous mycobacteria isolated from clinical specimens by MALDI-TOF mass spectrometry

Direct MALDI-TOF identification from positive blood culture bottles compared with conventional identification

Comparison of Ziehl-Neelsen staining and LED fluorescence microscopy with culture for diagnosis of pulmonary tuberculosis

Diagnostic accuracy of CBNAAT compared with liquid culture in extrapulmonary tuberculosis specimens

Prevalence of rifampicin resistance detected by CBNAAT among presumptive pulmonary tuberculosis patients

CBNAAT versus liquid culture in the diagnosis of extrapulmonary tuberculosis

Truenat MTB versus CBNAAT for detection of Mycobacterium tuberculosis and rifampicin resistance

Line probe assay for isoniazid and fluoroquinolone resistance among rifampicin-resistant tuberculosis isolates

Non-tuberculous mycobacteria in clinical samples: isolation rate, species and clinical significance

Fluorescent microscopy versus Ziehl-Neelsen staining for detection of acid-fast bacilli in sputum

Urine lipoarabinomannan assay for tuberculosis in HIV-infected patients

Diagnostic utility of CBNAAT on gastric aspirate in childhood pulmonary tuberculosis

CBNAAT on synovial fluid and tissue in suspected osteoarticular tuberculosis

Interferon-gamma release assay versus tuberculin skin test for latent tuberculosis among healthcare workers

Tuberculous meningitis: CSF CBNAAT, culture and adenosine deaminase in diagnosis

Genital tuberculosis in infertile women: endometrial biopsy CBNAAT, culture and histopathology

Bacterial co-infection in sputum of newly diagnosed pulmonary tuberculosis patients

MALDI-TOF mass spectrometry versus conventional biochemical methods for identification of bacterial isolates

Multiplex PCR panel versus conventional culture in the diagnosis of bacterial meningitis

Direct identification and susceptibility testing from positive blood culture bottles and its effect on time to result

Molecular detection and genotyping of Orientia tsutsugamushi in patients with suspected scrub typhus

Loop-mediated isothermal amplification for detection of Mycobacterium tuberculosis in sputum

Rapid urine culture screening by flow cytometry versus conventional culture

Lateral flow assay for detection of carbapenemase types directly from bacterial colonies

Automated blood culture systems versus conventional culture: time to positivity and isolation rate

Truenat MTB Plus on extrapulmonary specimens for detection of tuberculosis and rifampicin resistance against liquid culture

Xpert MTB/XDR versus second-line line probe assay for detecting fluoroquinolone and isoniazid resistance in rifampicin-resistant tuberculosis

Diagnostic yield of CBNAAT on pleural fluid versus pleural biopsy in tuberculous pleural effusion

Time to MGIT culture positivity and its association with sputum smear grade and treatment outcome in pulmonary tuberculosis

Stool CBNAAT for the diagnosis of pulmonary tuberculosis in children unable to produce sputum

Latent tuberculosis infection by interferon-gamma release assay among household contacts of pulmonary tuberculosis patients

47-kDa gene nested PCR on eschar and whole blood versus IgM ELISA in the diagnosis of scrub typhus

Syndromic multiplex PCR panel versus conventional culture for lower respiratory tract specimens from ventilated patients

Real-time PCR versus IgM ELISA for Leptospira in the early phase of acute febrile illness

mecA PCR versus cefoxitin disc diffusion for detecting methicillin resistance in coagulase-negative staphylococci

Multiplex PCR for Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium in patients with genital discharge

Rapid Carba NP test versus modified carbapenem inactivation method for carbapenemase detection in Gram-negative bacilli

Sputum quality (salivary versus mucopurulent) and its effect on smear microscopy and CBNAAT positivity in presumptive pulmonary tuberculosis

CBNAAT on bronchoalveolar lavage in sputum-scarce and smear-negative presumptive pulmonary tuberculosis against liquid culture

Sodium hypochlorite concentration versus direct smear microscopy for detection of acid-fast bacilli in sputum

MGIT liquid culture versus Lowenstein-Jensen medium: recovery rate, time to detection and contamination rate of mycobacteria

MPT64 antigen immunochromatographic test for rapid identification of Mycobacterium tuberculosis complex from positive liquid cultures

CBNAAT on urine and urine culture in suspected genitourinary tuberculosis

Active case finding for pulmonary tuberculosis by symptom screening and CBNAAT among household contacts of notified patients

Semi-quantitative bacillary load on CBNAAT and its correlation with sputum smear grade and radiological extent of pulmonary tuberculosis

Bacteriological index on slit-skin smear and its association with clinical classification and lepra reactions in leprosy

Latent tuberculosis infection by interferon-gamma release assay among patients with rheumatic diseases before biologic or immunosuppressive therapy

Multiplex PCR gastrointestinal panel versus stool culture and microscopy in hospitalised patients with acute infectious diarrhoea

Rapid antigen detection test for group A streptococcus versus throat culture in children with acute pharyngitis

Broad-range 16S rRNA gene PCR versus culture of synovial fluid in suspected septic arthritis

Mycoplasma pneumoniae detection by real-time PCR in children with community-acquired pneumonia and its clinical profile

Bordetella pertussis detection by real-time PCR in infants and children with paroxysmal cough

Agreement of an automated identification and susceptibility system with reference broth microdilution for carbapenem MICs in Enterobacterales

Real-time PCR on whole blood versus blood culture for Salmonella Typhi and Paratyphi A in suspected enteric fever

Real-time PCR versus enriched culture for group B streptococcus in rectovaginal swabs of antenatal women at 35 to 37 weeks

Diagnostic accuracy of Truenat MTB Plus compared with liquid culture in extrapulmonary tuberculosis specimens at a tertiary care hospital

Bedaquiline and linezolid resistance-associated mutations among rifampicin-resistant Mycobacterium tuberculosis isolates by targeted next-generation sequencing

Mutation patterns in rpoB, katG and inhA genes among drug-resistant Mycobacterium tuberculosis isolates and their association with clinical risk factors

Species identification of non-tuberculous mycobacteria from liquid culture isolates by MALDI-TOF mass spectrometry compared with line probe assay

Diagnostic yield of stool-based nucleic acid amplification testing compared with gastric aspirate for paediatric pulmonary tuberculosis

Diagnostic performance of a multiplex PCR syndromic panel compared with conventional methods in cerebrospinal fluid of suspected meningitis and encephalitis

EUCAST rapid antimicrobial susceptibility testing directly from positive blood cultures compared with standard disc diffusion in Gram-negative bacteraemia

Rapid detection of carbapenemase genes directly from positive blood cultures by multiplex real-time PCR compared with phenotypic tests

Loop-mediated isothermal amplification for detection of Orientia tsutsugamushi in blood compared with IgM ELISA in acute febrile illness

Real-time PCR for detection of Burkholderia pseudomallei compared with culture in patients with suspected melioidosis

Species distribution of rapidly growing non-tuberculous mycobacteria from clinical samples and their susceptibility to amikacin, clarithromycin and linezolid

Frequency of active tuberculosis detected by CBNAAT and liquid culture of respiratory specimens among patients with newly diagnosed lung carcinoma