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MD · Para-clinical

IHC & Molecular Pathology Thesis Topics for MD Pathology — 80+ titles

Updated November 2026 · reviewed against the current NMC / NBE curriculum

Hand-curated database of 80+ MD Pathology (IHC & Molecular Pathology) dissertation titles, each ready with objectives, synopsis structure and protocol guidance. Unlock the objectives of any title instantly, or get the complete thesis plan — no signup.

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MD Pathology (IHC & Molecular Pathology) — Thesis Title List

80 titles · instant objectives
  1. 001

    Pattern of cervical precancerous lesions on cervical biopsy with p16 immunohistochemistry

    Immunohistochemistry & Molecular Pathology Prospective observational study Clinical Spectrum / Profile
    Objective
  2. 002

    Expression of Ki-67 in thyroid neoplasms and its correlation with histopathological type

    Immunohistochemistry & Molecular Pathology Prospective observational study Clinical Spectrum / Profile
    Objective
  3. 003

    Association of ER, PR and HER2 status with histological grade and lymph node status in invasive breast carcinoma

    Immunohistochemistry & Molecular Pathology Community-based cross-sectional study Community / KAP
    Objective
  4. 004

    Correlation of Ki-67 index with molecular subtype in invasive breast carcinoma

    Immunohistochemistry & Molecular Pathology Prospective analytical study Outcome / Prognostic
    Objective
  5. 005

    Role of immunohistochemistry panel in subtyping of lymphoma in lymph node biopsies

    Immunohistochemistry & Molecular Pathology Hospital-based cross-sectional study Association / Correlation
    Objective
  6. 006

    Expression of HER2 in breast carcinoma with emphasis on HER2-low status and its association with clinicopathological factors

    Immunohistochemistry & Molecular Pathology Analytical cross-sectional study Association / Correlation
    Objective
  7. 007

    Androgen receptor expression in triple-negative breast carcinoma and its association with tumour grade and Ki-67

    Immunohistochemistry & Molecular Pathology Analytical cross-sectional study Association / Correlation
    Objective
  8. 008

    TRPS1 immunohistochemistry in breast carcinoma and its comparison with GATA3 as a breast lineage marker

    Immunohistochemistry & Molecular Pathology Analytical cross-sectional study Comparative Study
    Objective
  9. 009

    Ki-67 proliferation index in meningiomas and its correlation with WHO grade

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  10. 010

    p16 immunohistochemistry in cervical intraepithelial neoplasia and its role in grading cervical lesions

    Immunohistochemistry & Molecular Pathology Analytical cross-sectional study Diagnostic Accuracy
    Objective
  11. 011

    Mismatch repair protein expression by immunohistochemistry in colorectal carcinoma and its clinicopathological correlates

    Immunohistochemistry & Molecular Pathology Analytical cross-sectional study Association / Correlation
    Objective
  12. 012

    PD-L1 expression in oral squamous cell carcinoma and its association with tumour stage and nodal status

    Immunohistochemistry & Molecular Pathology Analytical cross-sectional study Association / Correlation
    Objective
  13. 013

    Immunohistochemical expression of BCL-2 and CD10 in diffuse large B-cell lymphoma and cell-of-origin classification by the Hans algorithm

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Clinical Spectrum / Profile
    Objective
  14. 014

    CK7 and CK20 immunoprofile in carcinomas of unknown primary and its utility in predicting site of origin

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Diagnostic Accuracy
    Objective
  15. 015

    Immunohistochemical expression of p53 and Ki-67 in urothelial carcinoma and its association with grade and stage

    Immunohistochemistry & Molecular Pathology Analytical cross-sectional study Association / Correlation
    Objective
  16. 016

    Immunohistochemistry on cell blocks of serous effusions in distinguishing reactive mesothelial cells from metastatic carcinoma

    Immunohistochemistry & Molecular Pathology Prospective analytical study Diagnostic Accuracy
    Objective
  17. 017

    Calretinin immunohistochemistry in the diagnosis of Hirschsprung disease on rectal biopsies

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Diagnostic Accuracy
    Objective
  18. 018

    Estrogen and progesterone receptor expression in endometrial carcinoma and its association with histological grade

    Immunohistochemistry & Molecular Pathology Analytical cross-sectional study Association / Correlation
    Objective
  19. 019

    IDH1 R132H and ATRX immunohistochemistry in diffuse gliomas and integration with histological diagnosis

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Clinical Spectrum / Profile
    Objective
  20. 020

    PRAME and SOX10 immunohistochemistry in distinguishing cutaneous melanoma from benign melanocytic naevi

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Diagnostic Accuracy
    Objective
  21. 021

    p53 immunohistochemistry patterns in endometrial carcinoma as a surrogate for molecular classification and their association with histological type

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  22. 022

    HER2 immunohistochemistry in gastric and gastro-oesophageal junction adenocarcinoma and its association with Lauren histological type

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  23. 023

    INSM1 versus synaptophysin and chromogranin immunohistochemistry in the diagnosis of neuroendocrine neoplasms

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Comparative Study
    Objective
  24. 024

    PD-L1 combined positive score in squamous cell carcinoma of the cervix and its association with FIGO stage

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  25. 025

    STAT6 immunohistochemistry in the diagnosis of solitary fibrous tumour and its distinction from histological mimics

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Diagnostic Accuracy
    Objective
  26. 026

    WT1, PAX8 and p53 immunoprofile in high-grade serous carcinoma versus other ovarian epithelial tumours

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Diagnostic Accuracy
    Objective
  27. 027

    MYC and BCL2 dual expression in diffuse large B-cell lymphoma and its association with clinical stage and International Prognostic Index

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  28. 028

    HER2 immunohistochemical expression in urothelial carcinoma and its association with grade and muscle invasion

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  29. 029

    Ki-67 index versus mitotic count for grading gastroenteropancreatic neuroendocrine tumours: a concordance study

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Comparative Study
    Objective
  30. 030

    EGFR mutation testing by real-time PCR in non-small cell lung carcinoma biopsies and its association with histological subtype and smoking

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  31. 031

    ALK D5F3 immunohistochemistry in lung adenocarcinoma and its concordance with fluorescence in situ hybridisation

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Diagnostic Accuracy
    Objective
  32. 032

    CD117 and DOG1 immunohistochemical expression in gastrointestinal stromal tumours and association with risk category

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  33. 033

    ERG immunohistochemistry in prostatic adenocarcinoma and its association with ISUP grade group and serum PSA

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  34. 034

    Mismatch repair protein immunohistochemistry in endometrial carcinoma and its association with histological type, grade and myometrial invasion

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  35. 035

    PD-L1 (22C3) tumour proportion score in non-small cell lung carcinoma biopsies and its association with histological subtype and EGFR mutation status

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  36. 036

    BRAF V600E (VE1) immunohistochemistry in papillary thyroid carcinoma and its association with histological variant and extrathyroidal extension

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  37. 037

    NKX3.1 versus PSA immunohistochemistry in establishing prostatic origin of metastatic carcinoma in biopsy specimens

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Diagnostic Accuracy
    Objective
  38. 038

    SATB2 versus CDX2 immunohistochemistry in identifying colorectal origin of metastatic adenocarcinoma

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Diagnostic Accuracy
    Objective
  39. 039

    p40 versus p63 immunohistochemistry in distinguishing squamous cell carcinoma from adenocarcinoma in small lung biopsies

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Comparative Study
    Objective
  40. 040

    TTF-1 and Napsin A immunohistochemistry in distinguishing primary lung adenocarcinoma from metastatic adenocarcinoma in lung biopsies

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Diagnostic Accuracy
    Objective
  41. 041

    Cyclin D1 and SOX11 immunohistochemistry in the diagnosis of mantle cell lymphoma and its distinction from other small B-cell lymphomas

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Diagnostic Accuracy
    Objective
  42. 042

    Immunohistochemical profile of classical Hodgkin lymphoma with CD15, CD30, PAX5 and EBV-LMP1 and its association with histological subtype

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Clinical Spectrum / Profile
    Objective
  43. 043

    Hot-spot versus global scoring of Ki-67 index in invasive breast carcinoma according to International Ki67 in Breast Cancer Working Group recommendations

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Comparative Study
    Objective
  44. 044

    HER2 FISH amplification in breast carcinomas with equivocal (2+) immunohistochemistry according to ASCO/CAP guidelines and associated clinicopathological features

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Diagnostic Accuracy
    Objective
  45. 045

    E-cadherin immunohistochemistry in distinguishing invasive lobular from invasive ductal breast carcinoma

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Diagnostic Accuracy
    Objective
  46. 046

    p16 immunohistochemistry as a surrogate marker of HPV in oropharyngeal squamous cell carcinoma and its clinicopathological correlates

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  47. 047

    p53 and Ki-67 expression across grades of oral epithelial dysplasia and oral squamous cell carcinoma

    Immunohistochemistry & Molecular Pathology Analytical cross-sectional study Association / Correlation
    Objective
  48. 048

    Claudin 18.2 expression by immunohistochemistry in gastric adenocarcinoma and its association with HER2 status and tumour stage

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  49. 049

    HER2 overexpression in colorectal adenocarcinoma and its association with tumour location, grade and stage

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  50. 050

    Microvessel density by CD34 immunohistochemistry in colorectal carcinoma and its association with tumour stage and nodal metastasis

    Immunohistochemistry & Molecular Pathology Analytical cross-sectional study Association / Correlation
    Objective
  51. 051

    Immunohistochemistry versus Giemsa staining for detection of Helicobacter pylori in gastric biopsies with chronic gastritis

    Immunohistochemistry & Molecular Pathology Prospective analytical study Comparative Study
    Objective
  52. 052

    CD68 and CD163 tumour-associated macrophages in oral squamous cell carcinoma and their association with nodal metastasis and grade

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  53. 053

    Loss of PTEN expression in endometrial hyperplasia and endometrioid carcinoma and its diagnostic role in atypical hyperplasia

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  54. 054

    AMACR (racemase) and p63 immunohistochemistry in the diagnosis of small foci of adenocarcinoma in prostatic needle biopsies

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Diagnostic Accuracy
    Objective
  55. 055

    Glypican-3, HepPar-1 and arginase-1 immunohistochemistry in differentiating hepatocellular carcinoma from metastatic carcinoma in liver biopsies

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Diagnostic Accuracy
    Objective
  56. 056

    Inhibin and calretinin immunohistochemistry in the diagnosis of ovarian sex cord-stromal tumours and their distinction from mimics

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Diagnostic Accuracy
    Objective
  57. 057

    Immunohistochemical subtyping of ampullary carcinoma into intestinal and pancreatobiliary types using CK7, CK20, CDX2 and MUC1

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Clinical Spectrum / Profile
    Objective
  58. 058

    KRAS mutation analysis by real-time PCR in colorectal carcinoma and its association with clinicopathological features and MMR status

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  59. 059

    Mismatch repair deficiency by immunohistochemistry in gastric adenocarcinoma and its association with Lauren histological type and stage

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  60. 060

    PD-L1 (22C3) combined positive score in triple-negative breast carcinoma and its association with tumour-infiltrating lymphocytes

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  61. 061

    Nuclear beta-catenin immunohistochemistry in distinguishing desmoid fibromatosis from other fibroblastic and spindle cell lesions

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Diagnostic Accuracy
    Objective
  62. 062

    HBME-1, galectin-3 and CK19 immunohistochemistry in differentiating benign from malignant follicular-patterned thyroid lesions

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Diagnostic Accuracy
    Objective
  63. 063

    COX-2 immunohistochemical expression along the colorectal adenoma-carcinoma sequence and its association with dysplasia grade

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  64. 064

    Residual cancer burden after neoadjuvant chemotherapy in breast carcinoma and its association with pre-treatment Ki-67 and molecular subtype

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  65. 065

    Concordance of ER, PR and HER2 status between core needle biopsy and subsequent excision specimens in invasive breast carcinoma

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  66. 066

    CK5/6 and EGFR immunohistochemistry for identifying the basal-like phenotype in triple-negative breast carcinoma and its association with grade

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  67. 067

    Somatostatin receptor 2A immunohistochemistry in gastroenteropancreatic neuroendocrine tumours and its association with WHO grade

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  68. 068

    Claudin 18.2 immunohistochemical expression in gastric and gastro-oesophageal junction adenocarcinoma and its clinicopathological correlation

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  69. 069

    Frequency of mismatch repair protein deficiency by immunohistochemistry in colorectal carcinoma among patients younger than 50 years

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Clinical Spectrum / Profile
    Objective
  70. 070

    Immunohistochemical expression of SATB2 and CDX2 in differentiating colorectal from non-colorectal metastatic adenocarcinomas

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Diagnostic Accuracy
    Objective
  71. 071

    PD-L1 combined positive score in urothelial carcinoma of the urinary bladder and its correlation with grade, muscle invasion and tumour-infiltrating lymphocytes

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  72. 072

    HER2 immunohistochemical expression and HER2-low status in ovarian and endometrial serous carcinomas at a tertiary care centre

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Clinical Spectrum / Profile
    Objective
  73. 073

    HER2 immunohistochemical expression in gallbladder carcinoma and its association with tumour grade, stage and lymph node status

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  74. 074

    Concordance between manual counting and digital image analysis for Ki-67 proliferation index in invasive breast carcinoma

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Comparative Study
    Objective
  75. 075

    Correlation between Ki-67 labelling index and mitotic count in head and neck squamous cell carcinoma and their association with tumour grade

    Immunohistochemistry & Molecular Pathology Analytical cross-sectional study Association / Correlation
    Objective
  76. 076

    BCL2 immunohistochemical expression in invasive breast carcinoma and its association with hormone receptor status, grade and molecular subtype

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  77. 077

    Cell-of-origin subtyping of diffuse large B-cell lymphoma by the Hans algorithm and its association with International Prognostic Index and extranodal disease

    Immunohistochemistry & Molecular Pathology Retrospective record-based study Association / Correlation
    Objective
  78. 078

    CD4 and CD8 tumour-infiltrating lymphocytes in oesophageal squamous cell carcinoma and their association with tumour stage and nodal status

    Immunohistochemistry & Molecular Pathology Analytical cross-sectional study Association / Correlation
    Objective
  79. 079

    Vasculogenic mimicry by CD31/PAS dual staining in colorectal adenocarcinoma and its association with tumour grade, budding and metastasis

    Immunohistochemistry & Molecular Pathology Analytical cross-sectional study Association / Correlation
    Objective
  80. 080

    Direct immunofluorescence versus immunohistochemistry for C3 and IgG deposition in skin biopsies of pemphigus group of disorders

    Immunohistochemistry & Molecular Pathology Prospective analytical study Comparative Study
    Objective

MD Pathology (IHC & Molecular Pathology) thesis — frequently asked questions

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80+ MD Pathology (IHC & Molecular Pathology) thesis topics are listed on this page, organised by subsection of the Pathology (IHC & Molecular Pathology) curriculum. Click "Get Objectives" on any title to unlock its aim, objectives and hypothesis instantly.

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Are these topics suitable for DNB, MD and FCPS Pathology (IHC & Molecular Pathology) candidates?

Yes — these Pathology (IHC & Molecular Pathology) dissertation titles are aligned with NMC, NBE and DNB Pathology (IHC & Molecular Pathology) curricula and are suitable for MD Pathology (IHC & Molecular Pathology), DNB Pathology (IHC & Molecular Pathology) and FCPS candidates alike. We can also tailor a title to your institution's preferred study design.

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